Poster Here

This is an exciting and varied role where you will be assisting our Sales Manager to provide technical and sales support to customers and distributors and to enhance Paraytec’s offering to the market.

Detaols here

Johan P. Boetker,† Marja Savolainen,† Vishal Koradia,†,‡ Fang Tian,† Thomas Rades,§ Anette Mullertz,† Claus Cornett,† Jukka Rantanen,† and Jesper Østergaard*,†

†Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences,University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

§School of Pharmacy, University of Otago, 18 Frederick Street, Dunedin 9054, New Zealand

Please find the event flyer here and the registration documents here

http://www.sciforum.net/conf/ecps2011

Articles b004, b005 and b008 relate to the system.

This article shows how a capillary electrophoresis instrument may be used in conjunction with UV area imaging to determine mobility, diffusion coefficient and charge of components in a mixture of small molecules. Downloadable from Chromatography Today with the link below

http://www.chromatographytoday.com/article_read/830/

The ActiPix™ SDI300 provides unique insights and understanding into the processes taking place at the liquid/surface interface.  It also enables erosion and dissolution to be visualized simultaneously.

Compact in design, the SDI300 system includes award winning ActiPix™ UV area technology, dissolution imaging sample holder and integrated syringe pump.  Real time quantitative recording and review of data is possible with the SDI300’s software.  The SDI300 uses a highly sensitive UV area imaging sensor to record, integrate and analyze a variety of complex processes.

To date, no technology on the market rivals the SDI300’s UV area imaging detector.  This unique capability enables quantitative imaging of surface phenomena for a diverse range of substances including APIs, tablets, formulations, gels, liquids, stents and patches.

“Distek’s intimate market knowledge, excellent reputation for providing innovative products with superb customer service, make them a ideal partner for establishing the SDI300 in our most important target market’ added Mebs Surve, Business Development Director for Paraytec.

“Distek is excited to expand our dissolution instrument offering with the addition of the state-of-the-art ActiPix™ SDI300,” says Jeff Seely, Global Sales and Marketing Manager, Distek, Inc.  “Ultimately, this partnership provides Distek and Paraytec with the great opportunity to leverage synergies to provide innovation and value to Distek’s customers.”

Dr Mebs Surve, Business Development Director for Paraytec explained ‘Our new contract analysis and contract research business is based on Paraytec’s ground breaking technologies for sizing biopharmaceuticals and nanoparticles and also for surface dissolution imaging. These services are designed for customers who have limited budgets but still have an ever pressing need for data. Our options range from routine data generation to more detailed investigative analysis.’

Paraytec are also offering a contract design service to help companies bring new products to market. ‘Our expertise in instrument design has allowed Paraytec to build a reputation for rapid, cost effective turnaround of custom design projects. These range from specialised detector design through to full electro-mechanical and optical systems including software’ said Mark Vaux, CEO of Paraytec.

For a free brochure or to discuss your enquiry in more detail, please contact info@paraytec.com. For more information, please visit our website, www.paraytec.com/products.

The ActiPix™ D100 is a patented UV area imager which is enabling scientists to accomplish novel and exciting research in microfluidics and nanotechnology.  

Mebs Surve, Business Development Director for Paraytec commented ‘the award endorses the ActiPix™ D100 is a powerful tool to enable novel applications.  What makes the award even more satisfying was that we were chosen by delegates who attended the show.’

Dermot Boylan, General Manager for ELRIG, congratulated Paraytec on scooping the award for best technology in show. ‘ We are particularly pleased as Paraytec were at the event as part of our ‘Innovation Zone’, designed to help new companies with interesting and innovative products and ideas to have low-cost access to major events. Places are competed for strongly and, in this case, the delegates clearly agreed with us that Paraytec have products to get excited about. We wish Mebs and the team every success!’

There is an increasing need within the biopharmaceutical industry for techniques which complement or enhance currently available techniques such as dynamic light scattering (DLS), size exclusion chromatography (SEC) and transmission electron microscopy (TEM) for monitoring the amount and extent of aggregation of therapeutic proteins and monoclonal antibodies. All of the techniques previously mentioned have limitations, e.g. it is not possible to determine size for proteins without dilution, they cannot be used in conjunction with in-line systems, e.g. GE AKTA explorers and also have limited application in the analysis of membrane proteins.

This application note outlines results with a test protein, myoglobin, using a technique developed by Paraytec for determining the hydrodynamic radius of species in solution. Repeatability and intermediate precision are reported, and the key factor influencing the accuracy of the method is documented. The technique measures the extent of Taylor dispersion of a plug of sample moving through a buffer solution. The extent of dispersion correlates directly with the hydrodynamic radius of the species.

http://www.paraytec.com/downloads/application-notes/

Presentations will be given by leading academic and industrial researchers. The meeting will discuss fundamental principles behind the technique, examples of analysis and interpretation of a range of sparingly soluble species and how this technique can assist pre-formulation labs develop better active pharmaceutical ingredients via a quality by design approach.

Jesper Ostergaard, Associate Professor at the Department of Pharmaceutics and Analytical Chemistry at the University of Copenhagen and symposium chair commented “UV imaging facilitates quantification of the drug substance immediately adjacent to the solid material (or drug formulation) and the recording of concentration gradients. In principle, this will allow for faster and more detailed studies of drug dissolution as compared to the traditional methods. We are looking forward to the symposium which will highlight recent applications and discuss the potential of this novel, interesting dissolution technology.“

Symposium details:

Time of symposium: Wednesday, May 19, 2010 at 13:30 – 17:00 hrs

Location: Benzon Auditorium,  Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen

The symposium program is available to view on:

http://www.farma.ku.dk/index.php/UV-imaging-a-new-approach-fo/7783/0/

The event is free to attend. To register, please email info@paraytec.com

The ActiPix™ SDI300 instrument is a unique UV area imaging detector which enables quantitative imaging of surface phenomena of a diverse range of substances including APIs, formulations, gels, liquids, stents and patches. 

Compact in design, the SDI300 system includes patented ActiPix™ UV area imaging detection, dissolution imaging sample holder, integrated syringe pump, and software which enables real time quantitative recording and review of data. The SDI300 uses a highly sensitive UV area imaging sensor to record, interrogate and analyse a variety of complex processes. Operating wavelength (190-1100 nm) can be selected to allow sensitive and selective monitoring of the substance of interest. It is the first tool of its kind to offer accurate, quantitative and mechanistic information for a variety of applications. Used as a tool for accelerated pre-formulation development the SDI300 is proven to enable intrinsic dissolution rates to be obtained in less than 20 minutes, a fraction of the time compared to conventional dissolution systems. The ActiPix™ SDI300  provides unique insights into processes taking place from microns to millimetres from the surface, the key distance range for understanding dissolution, and enables both erosion and dissolution to be vizualised simultaneously.